E-052 was found through one of James' few video games that retells the story so far within our universe, being one of the enemies. It has never interacted with the real world, but they are represented as the person who set off the curse.
E-052 is a drawing representing Wario for one of James' video games retelling the story of what happened to Wario. In the game, it has appeared on the left door only. This entity can jumpscare you, but it is not harmful.